![]() Note: Pharmacokinetic analysis based on simulation reported that the following age-dependent pediatric doses resulted in exposures similar to adult doses of 30 to 150 mg/day: Children >6 to 12 years: 0.4 to 1.9 mg/kg/day and Adolescents: 0.4 to 2.1 mg/kg/day ( Ref) experiential data are needed to fully assess. When used for palliative care, multiple daily doses may be necessary in patients >18 years of age, 25 to 50 mg/dose increased gradually to twice or 3 times daily as needed (do not exceed adult dosing) ( Ref). ![]() Due to possible risk of QT prolongation, it is suggested to avoid or use with caution in patients with Rett syndrome ( Ref).Ĭhildren 18 months to 5 years and Adolescents: Oral: Immediate release: Initial: 0.75 to 1 mg/kg/dose or 25 to 50 mg at bedtime may increase at 2-week intervals in 12.5 to 25 mg increments up to a maximum dose of 200 mg/dose reported range: 0.5 to 2 mg/kg/ day ( Ref). Keep from freezing.ĭo not keep outdated medicine or medicine no longer needed.Īsk your healthcare professional how you should dispose of any medicine you do not use.Insomnia sleep disturbances: Limited data available frequently used clinically in children with comorbid neuropsychiatric disorders (eg, autistic spectrum disorders, neurogenetic disorders, mood disorders, anxiety disorders, developmental delay with attention-deficit hyperactivity disorder) ( Ref). Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. If you miss a dose of this medicine, take it as soon as possible. However, the dose is usually not more than 400 mg per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 375 mg per day.Ĭhildren-Use and dose must be determined by your doctor.Īdults-At first, 150 milligrams (mg) per day, given in divided doses. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.įor oral dosage form (extended-release tablets):Īdults-At first, 150 milligrams (mg) per day as a single dose. The amount of medicine that you take depends on the strength of the medicine. If your dose is different, do not change it unless your doctor tells you to do so. The following information includes only the average doses of this medicine. Follow your doctor's orders or the directions on the label. The dose of this medicine will be different for different patients. Do not break the tablet unless your doctor tells you to. The tablet can be swallowed whole or given as a half tablet by breaking the tablet along the score line. Take the extended-release tablet at the same time each day, preferably at bedtime, without food. To lessen stomach upset and to reduce dizziness and lightheadedness, take the regular tablet with or shortly after a meal or light snack. Ask your doctor or pharmacist if you have any questions. Read and follow these instructions carefully. This medicine should come with a Medication Guide.
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